Chien-Shiung Wu   was a Chinese-American  experimental physicist  who made significant contributions in the field of  nuclear physics. Wu worked on the  Manhattan Project, where she helped develop the process for separating  uranium  metal into  uranium-235  and  uranium-238 isotopes  by  gaseous diffusion. She is best known for conducting the  Wu experiment, which contradicted the hypothetical  law of conservation of parity. This discovery resulted in her colleagues  Tsung-Dao Lee  and  Chen-Ning Yang  winning the 1957  Nobel Prize in physics, and earned Wu the inaugural  Wolf Prize in Physics  in 1978. Her expertise in experimental physics evoked comparisons to  Marie Curie. Her nicknames include "the First Lady of Physics", "the Chinese Madame Curie", and the "Queen of Nuclear Research".